New water-soluble chitin derivative with high antibacterial properties for potential application in active food coatings

The synthesis of new chitin derivatives through ultrasound-assisted treatment of the chitin with 1-azido-3-chloropropan-2-ol under Green Chemistry conditions is described. This is the first example of ultrasound-assisted polymer analogues transformation of chitin unaccompanied by noticeable backbone degradation or deacetylation. The obtained water-soluble azido chitin derivatives are characterized by high antibacterial activity, which is comparable with that of commercial antibiotics ampicillin and gentamicin. At the same time, they were demonstrated almost identical in vitro toxicity as unmodified chitin and chitosan. The antibacterial activity of the obtained polymers is mainly provided by azido moiety in their macromolecules. The conjugation of azido moiety to chitin backbone strongly diminishes the toxicity of the azido pharmacophore, but preserves its antibacterial properties. The most potent chitin derivative was used for the film coating of Ricotta cheese samples. This food coating proved to be efficient for the prolongation of shelf life of Ricotta cheese. © 2020 Elsevier Ltd

Kritchenkov A.S. 1, 2, 3 , Kletskov A.V. 1 , Egorov A.R. 1 , Tskhovrebov A.G. 4 , Kurliuk A.V.5 , Zhaliazniak N.V.5 , Shakola T.V.5 , Khrustalev V.N. 1, 6
Elsevier Ltd
  • 1 Peoples’ Friendship University of Russia (RUDN University), Miklukho-Maklaya St. 6, Moscow, 117198, Russian Federation
  • 2 Saint Petersburg National Research University of Information Technologies, Mechanics, and Optics, Kronverkskii pr. 49, St. Petersburg, 197101, Russian Federation
  • 3 Institute of Technical Acoustics, NAS of Belarus, Ludnikova Prosp. 13, Vitebsk, 210009, Belarus
  • 4 N. N. Semenov Federal Research Center for Chemical Physics, Russian Academy of Sciences, Kosygina Street 4, Building 1, Moscow, 119991, Russian Federation
  • 5 Vitebsk State Medical University, Frunze av. 27, Vitebsk, 210009, Belarus
  • 6 Zelinsky Institute of Organic Chemistry RAS, Leninsky Prosp. 47, Moscow, 119991, Russian Federation
Ключевые слова
Active coatings; Antibacterial activity; Chitin; Chitin derivatives; Food coatings
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