The therapeutic potential of curcumin for the treatment of glioblastoma multiforme [Терапевтический потенциал куркумина для лечения мультиформной глиобластомы]

Glioblastoma multiforme (GBM), a grade IV astrocytoma, is the most common and deadly type of primary malignant brain tumor, with a patien’s median survival rate ranging from 12 to 15 months. Over the last fifteen years, the treatment for GBM has included maximal safe surgical resection with combination radiotherapy and adjuvant temozolomide chemotherapy. The low efficacy of mentioned therapies has forced researchers to explore an appropriate alternative or complementary treatment for GBM. It has been shown that curcumin has therapeutic potentials to fight against GBM via affecting on cell proliferation, apoptosis, cell cycle, invasion and angiogenesis pathways. In addition, curcumin possess a synergistic impact with chemotherapeutic agents. Herein, we summarized the current findings on curcumin as potential therapeutic agent in the treatment of GBM. © 2020 ABC-press Publishing House. All rights reserved.

Авторы
Kushnir T.I. 1, 2 , Arnotskaya N.E.1 , Kudryavtsev I.A.1 , Shevchenko V.E.1
Издательство
Общество с ограниченной ответственностью "Издательский дом "АБВ-пресс"
Номер выпуска
1
Язык
Русский
Страницы
8-16
Статус
Опубликовано
Том
7
Год
2020
Организации
  • 1 Research Institute of Carcinogenesis, N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia, Build. 15, 24 Kashirskoe Shosse, Moscow, 115478, Russian Federation
  • 2 Institute of Biochemical Technology and Nanotechnology, Peoples’ Friendship University of Russia, Build. 2, 10 Miklukho-Maklaya St., Moscow, 117198, Russian Federation
Ключевые слова
Angiogenesis; Apoptosis; Curcumin; Glioblastoma multiforme; Invasion
Дата создания
20.04.2021
Дата изменения
20.04.2021
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/72687/
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Sulima A.N., Zhukov O.B., Rybalka A.N.
Опухоли женской репродуктивной системы. Общество с ограниченной ответственностью "Издательский дом "АБВ-пресс". Том 21. 2020. С. 31-39