Modification of choline derivatives and the study of the pharmacological activity

Organic molecules have biological activity to basis of a known molecule, and others are associated with the type and orientation of additive modifications. However, acetylcholine (ACh) is the main neurotransmitter of the parasympathetic nervous system, the part of the autonomic nervous system that contracts smooth muscles, dilates blood vessels, increases body secretion, and slows the heartrate. In the central nervous system, A Chhasseverali abnormal deficiency of ACh in the brain in people with Alzheimer's disease. In the past, it has been attempted to use Ach chloride ascholmergic stimulants.biit.un short action duration due to its rapid hydrolysis by acetylcholinesterase (ACliE) enzymes and the lack of specificity. © 2020, International Journal of Pharmaceutical Quality Assurance. All rights reserved.

Авторы
Издательство
International Journal of Pharmaceutical Quality Assurance
Номер выпуска
3
Язык
Английский
Страницы
1-12
Статус
Опубликовано
Том
11
Год
2020
Организации
  • 1 Department of Pharmaceutical Chemistry and Pharmacognosy of the Center for Collective Use (SEC) of the RUDN University, Russian Federation
  • 2 Center for Collective Use (Scientific and Educational Center) of RUDN. Doctor of Pharmaceutical Sciences, Russian Federation
  • 3 Department of Technology for Preparation of Medicines and Organization of Pharmaceutical Business, Faculty of Advanced Training of Medical Workers, Peoples’ Friendship, University of Russia, Russian Federation
  • 4 Department of Pharmaceutical Chemistry and Pharmacognosy, Center for Collective Use (SEC), RUDN, Russian Federation
  • 5 Department of Public Health, Healthcare and Hygiene, Russian Federation
Ключевые слова
Alzheimer disease; Choline; Choline Acetyltransferase; Choline Esterase; EDTA chelating agent; Modification
Дата создания
20.04.2021
Дата изменения
20.04.2021
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/72642/
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