Synthesis, spectral and quantum chemical researches of (Z)-10-(2-(4-amino-5- thioxo-4,5-dihydro-1h-1,2,4-triazole-3-il)hydrazono)-9-phenanthrone

(Z)-10-(2-(4-amino-5-thioxo-4,5-dihydro-1H-1,2,4-triazole-3-il)hydrazono)-9-phenanthrone (I) was obtained by a condensation of 4-amino-5-hydrazino-4H-1,2,4-triazole-3-thiol with 9,10-phenanthrenequinone. The compound I was characterized by IR, UV-VIS, 1H, 13C NMR and chromatography-mass spectrometry. The electronic absorption spectra of I in aproton solvents (DMF, DMSO) are characterized by the existence of an intensive long-wave band in the range of 468 - 485 nm. The absorption maximum of a freshly prepared solution of I (485 nm) after 48 h gradually undergoes hypsochromic shift to 474 nm, and after 72 h it shifts to 468 nm. In the UVVIS spectrum of I, at addition of NaOH the batochromic shift of a long wave band to 511 nm with a significant increase in intensity is observed. The presence of one isobestic point in the spectrum indicates the formation of a mono-anion. In the UV-VIS spectrum of I at addition of HCl solution, the long wave absorption band undergoes hypsochromic shift to 376 nm with a small decrease in intensity. In the 1H NMR spectrum of I, in the range of 15.08 ppm a singlet signal of a proton of a hydrazo-group is observed. In the 13C NMR spectrum of I, in the range of 180.80 ppm a signal which corresponds to carbonyl C-atom is observed. Quantum chemical modeling of the electronic structure of I as well as its ionic forms was performed in the frames of the density functional theory approach (DFT) using of a hybride tri-parametric exchange Becke functional with a correlational Lee-Yang-Parr functional (B3LYP) and basis sets def2-SV(P), def2-TZV(P). According to the spectral and quantum chemical studies, in the crystalline state and saturated solution the compound I exists in the form of the thione quinone hydrazone tautomer stabilized by intramolecular hydrogen bonds. The thione tautomer is 44 kJ/mol more stable than a thiol tautomer, the transition barrier is 135 kJ/mol. However, it is not possible to exclude possibility of transition of the thione form into the thiol one in the diluted solutions. © 2018, Ivanovo State University of Chemistry and Technology.

Polyanskaya N.A. 1 , Ryabov M.A. 1 , Strashnov P.V. 2 , Linko R.V. 1 , Davydov V.V. 1 , Kobrakov K.I.3 , Karavaeva E.B.3
Ivanovo State University of Chemistry and Technology
Номер выпуска
  • 1 Department of General Chemistry, RUDN University, Miklukho-Maklaya st., 6, Moscow, 117198, Russian Federation
  • 2 A. N. Nesmeyanov Institute of Organoelement Compounds of RAS, Vavilov st., 28, Moscow, 119334, Russian Federation
  • 3 Department of Organic Chemistry, Kosygin Russian State University, Mal. Kaluzhskaya st., 1, Moscow, 119071, Russian Federation
Ключевые слова
9,10-phenanthrenequinone; Heterocyclic compounds; Quantum chemical calculations; Spectral analysis; Triazole
Дата создания
Дата изменения
Постоянная ссылка