Oxidative stress is a key-factor in male infertility. The use of different substances with antioxidant activity has been studied as meth-ods of treatment of idiopathic forms of male infertility. The effectiveness of only a few of them can be considered as reliable. The aim of the study was a comparative assessment of two drugs — Spermactin Forte and Speroton. The choice was predetermined due to the highest content of L-carnitine in the composition of the preparations compared to other drugs on the Russian pharmaceu-tical market. A multicenter, randomized, comparative double-blind study in 80 men, aged 18 to 45 years. During the visits, the assessment of rou-tine sperm-tests and the fertilizing capacity of sperm was carried out by determining the reactive oxygen species, the level of sperm DNA fragmentation, and the HBA-test. The paper evaluates not only the effectiveness, but also the safety of the study drugs in the treatment of male infertility. © 2020, Media Sphera Publishing Group. All rights reserved.