Objective. To evaluate the effectiveness of systemic enzyme therapy in patients with chronic endometritis after missed abortion on the basis of morphological and immunohistochemical studies. Materials and methods. The study included 37 reproductive-aged women with missed miscarriage. Wobenzym was used in rehabilitation therapy after artificial abortion in 30 women. The conditions of the endometrium was studied by morphological and immunohistochemical methods before and after rehabilitation therapy. Results. The morphological signs of chronic inflammation were eliminated during the treatment with preparation Wobenzym; their elimination is confirmed by a decrease in the expression of HLA-DR and the disappearance of CD16+, CD20+, NK-lymphocytes and B-lymphocytes in the stroma. Indifferent endometrium in patients treated with Wobenzym was detected only in 6.7% of cases, secretory endometrium was detected in 73.3% of women, proliferative endometrium – in 26.7%. Conclusion. The use of Wobenzym after instrumental abortion in patients with endometritis and undeveloped pregnancy eliminates morphological signs of inflammation and promotes endometrial regeneration. © A group of authors, 2020.