The catalytic properties of plasma-chemically and thermally treated Bi4V2-2xCu2xO11–δ with х= 0.00–0.16 (BICUVOX) in the transformation of isobutanol are studied. Plasma treatments lead to the total deactivation of the active sites of dehydration reaction, and the alcohol is converted with 100% selectivity into aldehyde. Activity of the dehydrogenation of alcohol after PCT increases in ~ 1.7 times on samples with xCu=0.04-0.06 (α.β phases) compared to the initial samples. Similar values which were found for the samples with xCu=0.0-0.06, including the double vanadate, suggests that PCT affects the ceramic matrix with Bi, O and V elements. Addition of small amounts of copper does not change this effect. © 2018, Technical University of Kosice. All rights reserved.