According to the results of clinical studies published in the English and Russian literature in open databases the author has determined the significance and effectiveness of biochemical tests for the diagnosis of preterm birth. The definition of PAMG-1 for the diagnosis of preterm labor has sensitivity values of 84%, specificity is 95%, positive predictive value is 77% and negative prognosis is 97% and is a more reliable method than determining fFN, fPSIFR-1 or measuring cervical length and is associated with a reduction in financial costs. The use of the test kit for determining PAMG-1 is the most effective in comparison with other methods and allows to avoiding incorrect diagnosis and unnecessary hospitalization. © Bionika Media Ltd.