The bacteriophages in the treatment of peritonitis of appendicular origin

Due to development of laparoscopic techniques for the surgical treatment of acute appendicitis, the problem of the occurrence of early postoperative complications has not changed at present, which makes it necessary to carry out preventive measures. In the present study, one of the most frequent complications of acute appendicitis, peritonitis, has been modeled on the example of a biological model, with the aim of developing a method of preventive measures. The group of authors considered antibiotic prophylaxis, as well as an alternative method of preventive perioperative bacteriophage therapy. The evaluations method was based of the clinical picture study of the course of peritonitis in experimental animals, the pathomorphological and histological examination of the sectional peritoneum. As the study result, the authors did not reveal a significant difference in the methods of perioperative prophylaxis of complications of acute appendicitis, which makes possible to conduct monotherapy with bacteriophages, which is a promising direction in the face of ever increasing antibiotic resistance to antibacterial chemotherapy drugs.