Dehydration of Amides to Nitriles under Conditions of a Catalytic Appel Reaction

A highly expedient protocol for a catalytic Appel-type dehydration of amides to nitriles has been developed that employs oxalyl chloride and triethylamine along with triphenylphosphine oxide as a catalyst. The reactions are usually complete in less than 10 min with only a 1 mol % catalyst loading. The reaction scope includes aromatic, heteroaromatic, and aliphatic amides, including derivatives of α-hydroxy and α-amino acids. © 2018 American Chemical Society.

Авторы
Shipilovskikh S.A.1 , Vaganov V.Y.1 , Denisova E.I.1 , Rubtsov A.E.1 , Malkov A.V. 2, 3
Журнал
Номер выпуска
3
Язык
Английский
Страницы
728-731
Статус
Опубликовано
Том
20
Год
2018
Организации
  • 1 Department of Chemistry, Perm State University, Bukireva 15, Perm, 614990, Russian Federation
  • 2 Department of Chemistry, Loughborough University, Loughborough, Leicestershire, LE11 3TU, United Kingdom
  • 3 Department of Organic Chemistry, RUDN University, 6 Miklukho-Maklaya Street, Moscow, 117198, Russian Federation
Дата создания
19.10.2018
Дата изменения
19.10.2018
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/6861/
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