Genetic-based signatures of the latitudinal differences in chronotype

The natural cycles of night and day, and their length, remain stable in near-equatorial African regions but they vary with latitude and season in Eurasia. This new environmental factor might shape the adaptation of circadian rhythms of Eurasians after the out-of-African dispersal of their African ancestors. To identify the genetic-based signatures of this adaptation, geographic variation in allele frequencies of more than 2300 genetic variants was analyzed using data from 5 African and 11 Eurasian populations of the 1000 Genomes Project. The genetic signatures of latitude-dependent polygenic selection were found more frequently within non-coding DNA regions associated with morningness–eveningness in genome-wide association studies (GWASs) than among polymorphisms hinted by GWASs of other traits/diseases and among polymorphisms sampled from pseudogenes and from protein-coding regions in either circadian clock genes or reference genes. Some of such variants were located within the introgressions of the Neanderthal’s genome into the genomes of Eurasians. © 2018 Informa UK Limited, trading as Taylor & Francis Group

Putilov A.A.1 , Dorokhov V.B.2 , Puchkova A.N.2, 3 , Arsenyev G.N.2 , Sveshnikov D.S. 4
Taylor and Francis Ltd.
  • 1 Research Group for Math-Modeling of Biomedical Systems, The Research Institute for Molecular Biology and Biophysics, Novosibirsk, Russia
  • 2 Laboratory of Sleep/Wake Neurobiology, the Institute of Higher Nervous Activity and Neurophysiology of the Russian Academy of Sciences, Moscow, Russia
  • 3 Center for Cognition and Communication, Pushkin State Russian Language Institute, Moscow, Russia
  • 4 Department of Normal Physiology, Medical Institute, Peoples’ Friendship University of Russia, Moscow, Russia
Ключевые слова
1000 genomes project; latitudinal cline; migration out of Africa; morning–evening preference; Neanderthal’s genome; polygenic selection; skin pigmentation; SNP
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