Development and Validation of a Quantitative Determination Method for the Antitubercular Drug PBTZ169 in Biological Media

An HPLC-MS/MS method for quantitative determination of the new antituberculosis drug PBTZ169 in blood serum, urine, and feces using perindopril as an internal standard was developed and validated. The method was selective, specific, accurate, and precise. Calibration curves were linear in the ranges 2 – 2,000, 5 – 3,000, and 100 – 10,000 ng/mL for blood serum, urine, and feces, respectively, with correlation coefficients >0.99. The detection limits of PBTZ169 were 1, 2.5, and 50 ng/mL for serum, urine, and feces, respectively. The limits of quantitation were 2 ng/mL in serum; 5, urine; and 100, feces. © 2018, Springer Science+Business Media, LLC, part of Springer Nature.

Номер выпуска
3
Язык
Английский
Страницы
248-253
Статус
Опубликовано
Том
52
Год
2018
Организации
  • 1 People’s Friendship University of Russia, Common Use Center, Moscow, 117198, Russian Federation
Ключевые слова
antituberculosis drug; HPLC-MS/MS; PBTZ169; validation
Дата создания
19.10.2018
Дата изменения
19.10.2018
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/6609/