Immunohistopathological changes of bone tissue during chronic generalized periodontitis

The morphology of osteonecrotic processes and osteogenesis of experimental periodontitis with various degrees of severity were examined in 60 white outbred rats. In bone tissue of the alveolar process during chronic generalized periodontitis, immunohistomorphology revealed resorption processes with the participation of macrophages in the form of swelling and total lysis of osteocytes and histiocytes. Disruption of osteogenesis with insufficient bone neoplasm was noted during the progression of the disease, when along with intensive osteolytic processes, atypical bone formation was observed. Furthermore, in some areas of the bone tissue of the alveolar process, there was an inordinate change in resorption and bone-building processes. Therefore, a description of the pathological process in the form of «bone atrophy» does not reflect the pathology, whereas «osteoporosis and bone tissue repair» most accurately explains the mechanisms and manifestations of the pathological process of chronic generalized periodontitis. © Group of authors, 2019.

Авторы
Sirak S.V.1 , Shchetinin E.V.2 , Garunov M.M. 3 , Grigoryants L.A. 3 , Andreev A.A. 4 , Petrosyan G.G.2 , Dzgoeva M.G.5
Издательство
Stavropol State Medical University
Номер выпуска
3
Язык
Английский
Страницы
532-535
Статус
Опубликовано
Том
14
Год
2019
Организации
  • 1 Department of dentistry, Stavropol State Medical University, Russian Federation
  • 2 Department of pathophysiology, Stavropol State Medical University, Russian Federation
  • 3 Department of dentistry, Peoples’ Friendship University of Russia, Moscow, Russian Federation
  • 4 Stavropol State Medical University, Russian Federation
  • 5 Departament of dentistry, North Ossetian State Medical Academy, Vladikavkas, Russian Federation
Ключевые слова
Alveolar process; Bone; Osteoporosis; Periodontitis
Дата создания
02.11.2020
Дата изменения
02.11.2020
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/65801/