Using the properties of suture material as an example, it was shown that silver nanoparticles improve its antimicrobial and anti-inflammatory properties. In this work, we studied the properties of insulating membranes modified with silver nanoparticles. Polylactide membranes (n=12) were implanted into the skull of rabbits, of which six were not modified (control group) and six were coated with colloidal silver nanoparticles (experimental group). In the control group, rabbits were injected penicillin intramuscularly. The response of the skull tissues was evaluated after 2 weeks by microscopic and immunohistochemical (CD3, CD15, CD30) methods. In the experimental group, compared with the control group, inflammation indicators were significantly lower (CD3: 6.5±3.1 % and 17.3±5.2 %, p=0.03; CD30:3.1±1.4 % and 14.1±3.6 %, p=0.01), the fibroplastic reaction was less pronounced with no signs of connective tissue capsule formation, and no infectious complications were detected. In the control group, signs of infection were found in the area of the postoperative wound (n=1). The use of colloidal silver as an antimicrobial and anti-inflammatory coating for biodegradable membranes has potential, which requires further study. © 2019, Stavropol State Medical University. All rights reserved.