Position paper. The role of iron deficiency in patients with chronic heart failure and current corrective approaches

Further to the discussions, a position paper with the following main provisions was elaborated: 1. Iron Deficiency (ID) must be regarded as an independent clinically significant concomitant condition, with the prevalence reaching 50% among Chronic Heart Failure (CHF) patients in Russia. 2. According to observation studies iron deficiency in patients with CHF adversely affects functional performance and is associated with increased hospitalization rates and mortality. 3. ID must be excluded in all CHF patients, regardless of haemoglobin levels; the severity of ID should be evaluated. Blood ferritin concentration and transferrin saturation (TSAT, transferrin saturation coefficient) are currently optimal parameters for defining ID. 4. According to current data, therapy aimed only at increasing blood haemoglobin concentrations does not seem to have advantages in influencing the prognosis and clinical manifestations of CHF, while the elimination of ID in CHF patients leads to significant clinical benefits even in the absence of anaemia. 5. According to recently available data (the results of Randomized Clinical Trials, RCTs), the intravenous use of ferric carboxymaltose should be considered the most consistent approach for the treatment of ID in CHF patients. © 2020 Seoul National University. All rights reserved.

Mareev V.Yu.1 , Gilyarevskiy S.R.2 , Mareev Yu.V.3 , Begrambekova Yu.L.1 , Belenkov Yu.N.4 , Vasyuk Yu.A.5 , Galyavich A.S. 6 , Gendlin G.E.7 , Glezer M.G. 4 , Kobalava Zh.D. 8 , Lelyavina T.A.9 , Orlova Ya.A.1 , Fomin I.V. 10 , Shaposhnik I.I.11
KlinMed Consulting
Номер выпуска
  • 1 Lomonosov Moscow State University, Moscow, Russian Federation
  • 2 Russian Medical Academy of Postgraduate Education, Moscow, Russian Federation
  • 3 National Medical Research Center for Preventive Medicine, Moscow, Russian Federation
  • 4 Sechenov Moscow State Medical University, Moscow, Russian Federation
  • 5 Moscow State Medical and Dental University Named After Evdokimov, Moscow, Russian Federation
  • 6 Kazan State Medical University, Kazan, Russian Federation
  • 7 Russian National Research Medical University Named After Pirogov, Moscow, Russian Federation
  • 8 Russian State University of Peoples' Friendship, Moscow, Russian Federation
  • 9 Almazov National Medical Research Center, St. Petersburg, Russian Federation
  • 10 Nizhny Novgorod State Medical Academy, Nizhny Novgorod, Russian Federation
  • 11 Ural State Medical University, Chelyabinsk, Russian Federation
Ключевые слова
Anemia; Chronic heart failure; Ferric carboxymaltosate; Ferritin; Functional ability; Iron deficiency; Transferrin saturation
Дата создания
Дата изменения
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Другие записи

Yu T.I., Gromova O.A., Stakhovskaya L.V., Vanchakova N.P., Galustyan A.N., Kobalava Zh.D., Grishina T.R., Gromov A.N., Ilovaiskaya I.A., Kodentsova V.M., Kalacheva A.G., Limanova O.A., Maksimov V.A., Malyavskaya S.I., Mozgovaya E.V., Tapilskaya N.I., Rudakov K.V., Semenov V.A.
Фармакоэкономика. Современная фармакоэкономика и фармакоэпидемиология. Том 13. 2020. С. 146-163