Assessment of respiratory rate in dogs during the sleep with mitral valve endocardiosis, complicated by congestive heart failure syndrome: The degree of adherence for this test by animal owners and its impact on patient survival

Relevance: Congestive heart failure in dogs is an urgent problem for Doctor of Modern Veterinary cardiology. Endocardiosis, or myxomatous mitral valve degeneration, is the most common acquired heart disease of dogs that has a potential adverse outcome. Accurate and timely diagnosis for this cardiopathology in dogs, and also effective monitoring of the progression of congestive heart failure syndrome are the most important problems of veterinary medicine. Purpose of research: To study the commitment of owners whose dogs with mitral valve endocardiosis to assess the respiratory rate of their pets during sleep and its impact on the survival of sick animals. Materials and methods. A prospective study of the survival rate of 181 dogs with mitral valve endocardiosis, complicated by congestive heart failure syndrome. Results: It was found that the degree of owners' commitment to assess the respiratory rate during sleep has a significant impact on the survival of dogs with mitral valve endocardiosis. The median life expectancy of sick dogs whose owners had a high commitment to monitoring respiratory function was significantly high. The survival time of sick dogs whose owners showed high adherence to the test was on average 604.8±53.1 days (variation from 0 to 1378; median-452 days). In sick animals whose owners showed low adherence to assess the respiratory rate, the life expectancy was significantly low and averaged 279.9±28.9 days (variation from 0 to 1156; median-122 days). In the Mann-Whitney test, this difference was found to be significant (p<0.0001). When evaluating the survival curves of dogs with endocardiosis complicated by congestive heart failure, and with different owners' commitment to assess the respiratory rate during sleep, according to the Kaplan-Meyer method using the Gehan criterion, a highly reliable difference was found (p<0.0001). According to the results of multiple analysis of proportional Cox intensities, three independent predictors of fatal mitral valve endocardiosis in dogs complicated by congestive heart failure syndrome were identified: low adherence of dog owners to assess the respiratory rate during sleep; the presence of a decrease in the shortening fraction below 35%; an increase in the rate of tricuspid insufficiency above 4 m/s. Conclusion: The low degree of adherence of owners of sick dogs to assess the respiratory rate during sleep is the most powerful independent predictor of the fatal outcome of congestive heart failure in mitral valve endocardiosis. It is recommended to identify factors of low diagnostic adherence in owners in a timely manner and conduct explanatory work to improve it. © Advanced Scientific Research. All rights reserved.

Авторы
Rudenko A.1 , Rudenko P. 1, 2 , Glamazdin I.4 , Vatnikov Y. 2 , Kulikov E. 2 , Sachivkina N. 2, 3 , Rudenko V.1 , Sturov N. 5 , Babichev N.6 , Romanova E. 2 , Rusanova E. 5 , Lukina D. 2
Издательство
EManuscript Technologies
Номер выпуска
5
Язык
Английский
Страницы
358-367
Статус
Опубликовано
Том
11
Год
2020
Организации
  • 1 Biological Testing Laboratory, Branch of Shemyakin, Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences (BIBCh RAS), 6, Prospekt Nauki, Pushchino, Moscow region, 142290, Russian Federation
  • 2 Department of Veterinary Medicine, Peoples' Friendship University of Russia (RUDN University), 6, Miklukho-Maklaya street, Moscow, 117198, Russian Federation
  • 3 Department of Microbiology and Virology, Peoples' Friendship University of Russia (RUDN University), 6 MiklukhoMaklaya street, Moscow, 117198, Russian Federation
  • 4 Department of Veterinary Medicine, Moscow State University of Food Production, 11, Volokolamskoe highway, Moscow, 125080, Russian Federation
  • 5 Department of General Medical Practice, Peoples' Friendship University of Russia (RUDN University), 6, MiklukhoMaklaya street, Moscow, 117198, Russian Federation
  • 6 Sechenov First Moscow State Medical University, Bldg. 2, 8, Trubetskaya Street, Moscow, 119991, Russian Federation
Ключевые слова
acetylsalicylic acid; amlodipine; benazepril; digoxin; diltiazem; enalapril; furosemide; pimobendan; ramipril; sildenafil; spironolactone; torasemide; animal experiment; animal model; Article; breathing mechanics; breathing rate; clinical assessment; clinical evaluation; congestive heart failure; controlled study; dog; endocardiosis; endocarditis; female; fractional shortening; life expectancy; male; mitral valve endocardiosis; nonhuman; patient compliance; priority journal; respiratory function; sleep; sleep quality; survival rate; survival time; tricuspid valve regurgitation; valvular heart disease; veterinary medicine
Дата создания
02.11.2020
Дата изменения
02.11.2020
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/65513/
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