Among many veterinary science problems in the field of industrial pig breeding, the high incidence of uterine pig population with postpartum diseases is the main problem. The main causes are: increased microbial contamination of both habitat and birth canal, immunodeficiency caused by the impact on the body of the widespread use of chemotherapy and other xenobiotics, stresses of various etiologies. This work conducted to determine the effect of α-and γ – interferons of pork recombinant-the main active ingredients of the drug Biferon-C, selenium-containing drug Selecore and tissue preparation Aminoceletone, on the microbiocenosis of the reproductive tract, immunobiochemical, oxidative-antioxidant status, nitric oxide levels and the reproductive system of sows. The experiments were carried out in the conditions of the pig breeding enterprise of the Voronezh region on 56 crossbred sows of large white and Landrace breeds, which were taken in the experiment on the 103-105 day of gestation and divided into four groups. Sows of the first group (n=13) 8-10 days before farrowing were parenterally injected with α-and γ-recombinant pork interferons, the second (n=15) – α-and γ-interferons in combination with Aminoceletone, the third (n=14) – α-and γ-interferons in combination with Selector, the fourth (n=14) – drugs were not prescribed (control). At the beginning of the experiment (before the use of drugs) and on the third or fourth day after farrowing, blood samples were taken from five sows of each group. At the same time and before weaning pigs were sampled cervical mucus to determine the qualitative and quantitative composition of the microbiota. We took into account the onset of farrowing, the nature of the birth course and the postpartum period, the degree of development and safety of pigs, the presence of sows inflammatory processes in the genital organs, fertilization. It was found that the appointment of sows' drugs reduces the pressure of opportunistic and pathogenic microflora, stabilizes the normoflora of the genital tract, increases the immune status, reduces the formation of Malon dialdehyde in the body of animals and manifestations of endogenous intoxication, activation of antioxidant protection, optimization of NOx synthesis, resulting in a decrease in their incidence of postpartum diseases in 1,4-3,2 times, increased weight of pigs at weaning by 4,3-7,9%, increased their safety by 4,5-10,3%, reduced the onset of the sexual cycle by 0,5-1,3 days, the manifestation of a latent endometritis 1,4-3,2 fold increased fertility 9,4-11,1%. © 2020, Advanced Scientific Research. All rights reserved.