Dynamics of macrophage populations of the liver after subtotal hepatectomy in rats

Background: In many clinical cases of extensive liver resection (e.g. due to malignancy), the residual portion is too small to maintain the body homeostasis. The resulting acute liver failure is associated with the compensatory growth inhibition, which is a typical manifestation of the 'small for size' liver syndrome. The study investigates possible causes of the delayed onset of hepatocyte proliferation after subtotal hepatectomy (80% liver resection) in rats. Results: The data indicate that the growth inhibition correlates with delayed upregulation of the Tnf gene expression and low content of the corresponding Tnfα protein within the residual hepatic tissue. Considering the involvement of Tnf/Tnfα, the observed growth inhibition may be related to particular properties of liver macrophages - the resident Kupffer cells with CD68+CX1CR3-CD11b- phenotype. Conclusions: The delayed onset of hepatocyte proliferation correlates with low levels of Tnfα in the residual hepatic tissue. The observed growth inhibition possibly reflects specific composition of macrophage population of the liver. It is entirely composed of embryonically-derived Kupffer cells, which express the 'proregeneratory' M2 macrophage-specific marker CD206 in the course of regeneration. © 2018 The Author(s).

Elchaninov A.V. 1, 4 , Fatkhudinov T.K. 1, 4 , Usman N.Y.1 , Kananykhina E.Y.1 , Arutyunyan I.V. 1, 2 , Makarov A.V.1, 3 , Lokhonina A.V.1 , Eremina I.Z. 4 , Surovtsev V.V. 4 , Goldshtein D.V.5 , Bolshakova G.B.2 , Glinkina V.V.3 , Sukhikh G.T.1
BioMed Central Ltd.
Номер выпуска
  • 1 Gynecology and Perinatology named Academician V.I.Kulakov of Ministry of Health. of Russian Fed., National Medical Research Center for Obstetrics, 4 Oparina Street, Moscow, 117997, Russian Federation
  • 2 Scientific Research Institute of Human Morphology, 3 Tsurupa Street, Moscow, 117418, Russian Federation
  • 3 Pirogov Russian National Research Medical University, Ministry of Healthcare of the Russian Federation, 1 Ostrovitianov Street, Moscow, 117997, Russian Federation
  • 4 Peoples Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya Street, Moscow, 117198, Russian Federation
  • 5 Research Center of Medical Genetics, 1 Moscvorechie, Moscow, 115478, Russian Federation
Ключевые слова
Kupffer cells; Liver; Regeneration
Дата создания
Дата изменения
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