Polymorphism of the angiotensin-converting enzyme gene in muscovites with arterial hypertension and cardiovascular diseases

Insertion/deletion (I/D) polymorphism of the angiotensin I-converting enzyme (ACE) gene was studied in healthy individuals (N = 168) and in patients with myocardial infarction (N = 31), hypertrophic cardiomyopathy (N = 14), or arterial hypertension (N = 26) from Moscow and Moscow Region. Significant deviations: decreased homozygosity in the deletion-carrying allele (D/D, 19.2%) and increased heterozygosity (I/D, 65.4%), were only found in patients with arterial hypertension as compared with controls of the same sex and age (45.2% and 38.1%, respectively). A similar tendency was detected in postinfarction patients and those with cardiomyopathy. The paradoxical decrease in the frequency of D/D (an independent genetic marker of predisposition to cardiovascular diseases) can be explained by the age composition of the tested sample, because this genotype is associated with higher risk of premature death in older patients with hypertension and cardiopathies. The association of the ACE gene with angiopathies and the involvement of both genetic and nongenetic factors in the development of the above diseases were assumed.

Авторы
Chistyakov D.A. 1 , Demurov L.M.1 , Kondrat'ev Ya.Yu.2 , Kobalava Zh.D. 3 , Tereshchenko S.N. 3 , Moiseev V.S. 3 , Nosikov V.V.1
Редакторы
-
Журнал
Издательство
-
Номер выпуска
3
Язык
Английский
Страницы
334-337
Статус
Опубликовано
Подразделение
-
DOI
-
Номер
-
Том
32
Год
1998
Организации
  • 1 State Research Center GosNIIgenetika, Moscow, 113545, Russian Federation
  • 2 Endocrinology Research Center, Russian Academy of Medical Sciences, Moscow, 117036, Russian Federation
  • 3 Department of Internal Diseases, University of Peoples' Friendship, Moscow, 117272, Russian Federation
Ключевые слова
Angiotensin I-converting enzyme gene; Hypertension; Hypertrophic cardiomyopathy; Moscow population; Myocardial infarction
Дата создания
19.10.2018
Дата изменения
19.10.2018
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/652/