Ligand-Enabled Palladium-Catalyzed Through-Space C−H Bond Activation via a Carbopalladation/1,4-Pd Migration/C−H Functionalization Sequence

We report, herein, a palladium-catalyzed cascade comprising carbopalladation, 1,4-Pd-migration and C(sp2)−C(sp2) bond formation to construct a variety of bis-heterocyclic frameworks in a single operational step. The methodology provides a direct approach to introduce an oxadiazole core at a remote location without any functional group obligation, with moderate to good yields. © 2020 Wiley-VCH GmbH

Авторы
Chen S. 1 , Ranjan P.1 , Ramkumar N.1 , Van Meervelt L. , Van Der Eycken E.V. , Sharma U.K.1
Издательство
Wiley-VCH Verlag
Язык
Английский
Статус
Опубликовано
Год
2020
Организации
  • 1 Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, University of Leuven (KU Leuven), Celestijnenlaan 200F, Leuven, 3001, Belgium
  • 2 Biomolecular Architecture, Department of Chemistry, KU Leuven, Celestijnenlaan 200F, Leuven, 3001, Belgium
  • 3 Peoples' Friendship University of Russia (RUDN University), Miklukho-Maklaya Street 6, Moscow, 117198, Russian Federation
Ключевые слова
1,4-Pd migration; C−H activation; oxadiazoles; Pd-catalysis
Дата создания
02.11.2020
Дата изменения
02.11.2020
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/65167/
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Другие записи

Stefanuk V.L., Zhozhikashvily A.V., Savinitch L.V.
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). Том 12412 LNAI. 2020. С. 460-471