Ligand-Enabled Palladium-Catalyzed Through-Space C−H Bond Activation via a Carbopalladation/1,4-Pd Migration/C−H Functionalization Sequence

We report, herein, a palladium-catalyzed cascade comprising carbopalladation, 1,4-Pd-migration and C(sp2)−C(sp2) bond formation to construct a variety of bis-heterocyclic frameworks in a single operational step. The methodology provides a direct approach to introduce an oxadiazole core at a remote location without any functional group obligation, with moderate to good yields. © 2020 Wiley-VCH GmbH

Авторы
Chen S. 1 , Ranjan P.1 , Ramkumar N.1 , Van Meervelt L. , Van Der Eycken E.V. , Sharma U.K.1
Журнал
Chemistry - A European Journal
Издательство
Wiley-VCH Verlag
Язык
Английский
Статус
Опубликовано
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Внешняя ссылка
DOI
10.1002/CHEM.202001582
Год
2020
Организации
  • 1 Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, University of Leuven (KU Leuven), Celestijnenlaan 200F, Leuven, 3001, Belgium
  • 2 Biomolecular Architecture, Department of Chemistry, KU Leuven, Celestijnenlaan 200F, Leuven, 3001, Belgium
  • 3 Peoples' Friendship University of Russia (RUDN University), Miklukho-Maklaya Street 6, Moscow, 117198, Russian Federation
Ключевые слова
1,4-Pd migration; C−H activation; oxadiazoles; Pd-catalysis
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