The prospect of creating medicines based on selenium nanoparticles (Review)

Introduction. The prospects of using nanoparticles in the production of medicines are widely discussed in the literature. In 2018 alone, the quantity of registration certificates issued by national regulators for medicines that use nanoparticles in one form or another is around forty. Most of them are medicines based on liposomes, polymers, iron oxides, micelles. So far, no registration certificates have been issued for selenium nanoparticles. One of the reasons for this situation in this area, from our point of view, is that the mechanisms of interaction of nanoparticles with cells are not sufficiently studied. The lack of basic research in this area is one of the main obstacles to the development of new-generation drugs based on nanoparticles. Text. This review is devoted to the analysis of scientific data on the interaction of selenium nanoparticles with different types of cells. The article discusses the biological properties of selenium and its role in cell metabolism. Data on the cytotoxic effect of selenium nanoparticles on various cell cultures are presented. Methods of preparation of nanoparticles and methods for studying the interaction of nanoparticles with cell cultures are described. Conclusion. Analysis of the literature data allows us to draw conclusions about the relevance of research on the interaction of selenium nanoparticles with living cells. This is necessary to determine the mechanisms of selenium nanoparticles absorption, study their cytotoxic and / or cytostatic action, and distribution in cells. Investigation of the biological interaction of selenium nanoparticles with tumor and normal cells will determine the most informative methods for registering and quantifying their antitumor activity, which is relevant for the development of new drugs to treat cancer. © Skorinova K. D., Kuzmenko V. V., Vasilenko I. A., 2020.

Издательство
Общество с ограниченной ответственностью "Фармконтракт"
Номер выпуска
2
Язык
Русский
Страницы
33-44
Статус
Опубликовано
Том
9
Год
2020
Организации
  • 1 Peoples Friendship University of Russia (RUDN University), 6, Mikluho-Maklaya str, Moscow, 117198, Russian Federation
Ключевые слова
Biological properties of selenium nanoparticles; Cytostatic effect of selenium nanoparticles; Interaction of nanoparticles with cells; Research methods for nanoparticles with cells; Selenium; Selenium nanoparticles; Synthesis of selenium nanoparticles
Дата создания
02.11.2020
Дата изменения
02.08.2021
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/65035/
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Другие записи

Prisca K.F.J., Yurtaev Vladimir I.
Вопросы истории. Rossiiskaya Akademiya Nauk, Institut Istorii (Russian Academy of Sciences, Institute of General Hist. Том 2020. 2020. С. 134-143