Collagen Hydrolysis Products Reduce the Formation of Stress-Induced Ulcers by Regulating Stress-Associated Activation of the Neuroendocrine and Immune Systems

We studied the effect of collagen fragments (PGP and AcPGP) on serum content of epinephrine, corticosterone, and IL-1β in rats subjected to water-immersion stress. The degree of local inflammation accompanying ulceration was assessed by IL-1β production by ln. gastricus caudalis cells. In 1 h, the sharp increase in hormone concentrations in the blood of stressed animals reflected the high stress intensity. Intranasal administration of PGP reduced the area of stress-induced ulcers by 63%, prevented the increase in the levels of stress hormones and the main proinflammatory cytokine in rat blood. The concentrations of IL-1β in cell culture from regional lymph node of experimental animals returned to normal in 24 and 48 h after the stress. Acetylation of PGP prevents with gastroprotection, but does not abrogate other properties of the peptide. © 2018, Springer Science+Business Media, LLC, part of Springer Nature.

Редакторы
-
Издательство
New York Consultants BureauSpringer / Автономная некоммерческая организация Издательство Российской академии медицинских наук
Номер выпуска
4
Язык
Английский
Страницы
449-452
Статус
Опубликовано
Подразделение
-
Номер
-
Том
165
Год
2018
Организации
  • 1 Peoples Friendship University of Russia, Moscow, Russian Federation
  • 2 National Medical Research Center of Children’s Health, Ministry of Health of the Russian Federation, Moscow, Russian Federation
  • 3 Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology, and Immunology, Moscow, Russian Federation
Ключевые слова
corticosterone; epinephrine; IL-1β; PGP; stress ulcer
Дата создания
19.10.2018
Дата изменения
19.10.2018
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/6490/