Expression of Metalloproteinases and Type I and III Collagens during Healing of Excisional Skin Wound on the Abdomen and Back in Rats

The study was carried out using a novel rat model developed in our laboratory, namely16 mm diameter circular excisional wounds were generated on the abdomen which resulted in minimal scarring. Restoration of the skin integrity was completed by day 60 after the wounding surgery. By this time, regenerates on the abdomen were stronger than on the back (at, respectively, 58 and 17.4 % of the tensile strength of the intact skin at corresponding location) and the ratio of type I and type III collagens in regenerates on the abdomen reached the level of intact skin at the same location. On days 3 to 14, the ratio of Mmp9/Timp1 expression levels on the abdomen was higher than on the back. On days 20 and 30, the Mmp9/Timp1 ratio on the abdomen was identical to the level of intact skin, whereas the increased MMPs expression levels on the back were maintained until day 30. It has been shown for the first time that according to functional and molecular characteristics, wound healing on the abdomen of an adult rat is more similar to complete regeneration than scarring repair of the back skin. © 2020, Springer Science+Business Media, LLC, part of Springer Nature.

Kananykhina E.Y. 1, 2 , Shmakova T.V.1 , Bolshakova G.B. 1 , Rusanov F.S.3 , Elchaninov A.V. 2, 5 , Nikitina M.P. 1 , Lokhonina A.V. 2, 5 , Makarov A.V. 2, 4 , Fatkhudinov T.K. 1, 5
New York Consultants BureauSpringer / Автономная некоммерческая организация Издательство Российской академии медицинских наук
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  • 1 Research Institute of Human Morphology, Moscow, Russian Federation
  • 2 V. I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russian Federation, Moscow, Russian Federation
  • 3 Central Research Institute of Dentistry and Maxillofacial Surgery, Ministry of Health of Russian Federation, Moscow, Russian Federation
  • 4 N. I. Pirogov Russian National Research Medical University, Ministry of Health of Russian Federation, Moscow, Russian Federation
  • 5 Peoples’ Friendship University of Russia, Moscow, Russian Federation
Ключевые слова
abdomen; matrix metalloproteinases; regeneration; scar-free wound healing; skin
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