Comparative Analysis of the Paracrine Action of Neuronal and Glial Progenitor Cells Derived from Induced Human Pluripotent Stem Cells

We performed comparative analysis of paracrine activity of neuronal and glial progenitors derived from induced pluripotent stem cells under conditions of hypoxia modeled by addition of cobalt dichloride. Neuronal and glial progenitors produced neuroprotective and neurotrophic effects on SHSY-5Y neuroblastoma cells in co-culture during the post-hypoxic recovery and reduced the number of apoptotic and necrotic cells. Moreover, they produced a neurotrophic effect and promote the formation and growth of neurites in neuroblastoma cells. The paracrine effect of glial progenitors was more pronounced, which can be explained by more intensive expression and secretion of neurotrophic factors in these cells. © 2020, Springer Science+Business Media, LLC, part of Springer Nature.

Авторы
Salikhova D.I.1, 2 , Leonov G.E.1 , Bukharova T.B.1 , Bulatenko N.V.1 , Efremovа A.S.1 , Makhnach O.V.1 , Makarov A.V. 2 , Fatkhudinov T.H. 2, 3 , Goldshtein D.V. 1, 3
Издательство
New York Consultants BureauSpringer / Автономная некоммерческая организация Издательство Российской академии медицинских наук
Номер выпуска
1
Язык
Английский
Страницы
176-181
Статус
Опубликовано
Том
169
Год
2020
Организации
  • 1 N. P. Bochkov Research Center for Medical Genetics, Moscow, Russian Federation
  • 2 Research Institute of Human Morphology, Moscow, Russian Federation
  • 3 Peoples’ Friendship University of Russia (RUDN University), Moscow, Russian Federation
Ключевые слова
cell therapy; glial progenitors; induced pluripotent stem cells; neuronal progenitors; paracrine effect
Дата создания
02.11.2020
Дата изменения
02.11.2020
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/64785/
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Другие записи

Senyagin A.N., Larichev A.F., Smirnova I.P., Podoprigora I.V.
Бюллетень экспериментальной биологии и медицины Клеточные технологии в биологии и медицине. New York Consultants BureauSpringer / Автономная некоммерческая организация Издательство Российской академии медицинских наук. Том 169. 2020. С. 119-121