The lactobacillus brevis 47 f strain protects the murine intestine from enteropathy induced by 5-fluorouracil

We report that the results of our study indicate that Lactobacillus brevis 47 f strain isolated from the faeces of a healthy individual prevents the manifestations of experimental mucositis induced by treatment of Balb/c mice with the anticancer drug 5-fluorouracil (5 FU; 100 mg/kg i.p. × 3 days). The presence of damage to the intestine and the colon was determined by a morphometric analysis of specimens including the height of villi, the amount of goblet cells and infiltrating mononuclear cells, and the expression of the proliferative Ki-67 antigen. Changes in the lipid peroxidation in the blood and the intestine were determined by severalfold increase of the concentration of malonic dialdehyde. Oral administration of L.brevis 47 f strain prior to 5 FU decreased the drug-induced morphological and biochemical changes to their respective physiological levels; the ability of intestinal epitheliocytes to express Ki-67 was partially restored. These effects of L.brevis 47 f strain were more pronounced or similar to those of the reference compound Rebamipid, a quinoline derivative known to protect the gut from drug-induced toxicity. Thus, the new lactobacilli strain attenuates the severity of 5 FU-induced enteropathy. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.

Авторы
Marsova M.1 , Odorskaya M.1 , Novichkova M. 2 , Polyakova V.3 , Abilev S.1 , Kalinina E. 2 , Shtil A. 4, 5, 6 , Poluektova E.1 , Danilenko V. 1, 7
Журнал
Издательство
MDPI AG
Номер выпуска
6
Язык
Английский
Страницы
1-14
Статус
Опубликовано
Номер
876
Том
8
Год
2020
Организации
  • 1 Vavilov Institute of General Genetics, Russian Academy of Sciences, GSP-1, Moscow, 119991, Russian Federation
  • 2 Department of Biochemistry, Peoples’ Friendship University of Russia, RUDN University, Moscow, 117198, Russian Federation
  • 3 Department of Pathological Anatomy, Orenburg Medical University, Orenburg, 460014, Russian Federation
  • 4 Blokhin National Medical Research Center of Oncology, 24 Kashirskoye shosse, Moscow, 115478, Russian Federation
  • 5 Institute of Gene Biology, Russian Academy of Sciences, Moscow, 119334, Russian Federation
  • 6 Department of Chemistry, Moscow State University, 1-3 Leninskie Gory, Moscow, 119991, Russian Federation
  • 7 Faculty of Ecology, International Institute for Strategic Development of Sectoral Economics, Peoples’ Friendship University of Russia, RUDN University, Moscow, 117198, Russian Federation
Ключевые слова
5-fluorouracil; Antioxidants; Lactobacillus; Mucositis; Oxidative stress
Дата создания
02.11.2020
Дата изменения
02.11.2020
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/64701/
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Другие записи

Elchaninov A.V., Fatkhudinov T.K., Vishnyakova P.A., Nikitina M.P., Lokhonina A.V., Makarov A.V., Arutyunyan I.V., Kananykhina E.Y., Poltavets A.S., Butov K.R., Baranov I.I., Goldshtein D.V., Bolshakova G.B., Glinkina V.V., Sukhikh G.T.
PLoS ONE. Public Library of Science. Том 15. 2020.