Pyridine-Enabled C-N Bond Activation for the Rapid Construction of Amides and 4-Pyridylglyoxamides by Cooperative Palladium/Copper Catalysis

A pyridine-enabled C-N bond activation of peptidomimetics employing cooperative palladium/copper catalysis in water is developed. Diverse amides and 4-pyridylglyoxamides are simultaneously synthesized through two steps from commercially available materials in a rapid, environmentally friendly, and high atom-economical manner. Copyright © 2020 American Chemical Society.

Авторы
Song L. 1 , Claessen S. 1 , Van Der Eycken E.V.
Журнал
Journal of Organic Chemistry
Номер выпуска
12
Язык
Английский
Страницы
8045-8054
Статус
Опубликовано
Ссылка
Внешняя ссылка
DOI
10.1021/ACS.JOC.0C00845
Том
85
Год
2020
Организации
  • 1 Laboratory for Organic and Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, Ku Leuven, Celestijnenlaan 200F, Leuven, 3001, Belgium
  • 2 Peoples' Friendship University of Russia, Rudn University, Miklukho-Maklaya street 6, Moscow, 117198, Russian Federation
Ключевые слова
Amides; Catalysis; Palladium; Pyridine; Bond activation; Catalysis in water; Peptidomimetics; Rapid construction; Chemical activation; 4 pyridylglyoxamide; amide; copper; imine; oxidizing agent; palladium; peptidomimetic agent; pyridine; solvent; unclassified drug; water; Article; catalysis; chemical bond; chemical reaction; chemical structure; deprotonation; electron transport; oxidation; proton nuclear magnetic resonance; synthesis
Цитировать
ГОСТ MLA RIS BibTex
Поделиться

Другие записи