Issues of diagnosis and management of patients with neuroendocrine cell hyperplasia of infancy

Neuroendocrine hyperplasia of infancy (NEHI) is an interstitial lung disease (ILD) of unknown etiology, which develops in infancy and manifests as persistent tachypnea. Objective of the research: to summarize results of observations of patients with NEHI, including during the pandemic of a new coronavirus infectious disease (COVID-19). Materials and methods: clinical and follow-up observation, laboratory and instrumental examination, including lung biopsy, 52 children with NEHI aged from 21 days to 10 years. Results: NEHI more often affects boys in the first 6 months of life; can be diagnosed on the basis of pediatric ILD-syndrome detection; specific CT signs, lung biopsy. It is characterized by undulating course with increased respiratory failurec aused by acute respiratory viral infections, COVID-19; half of the patients need oxygen therapy. © 2020, Pediatria Ltd.. All rights reserved.

Ovsyannikov D.Y. 1, 2, 3 , Karpenko M.A.3 , Zhestkova M.A. 1 , Asherova I.K. 4 , Baychikova A.A. 1 , Daniel-Abu M. 1 , Gitinov S.A. 1, 3 , Zaitseva S.V.5 , Kovalenko I.V. 2 , Kustova O.V.6 , Malakhov A.B.7 , Osmanov I.M.8 , Pavlova E.S. 3 , Petryaykina E.E. 1, 2 , Popova V.V.8 , Rtishchev A.Y.2 , Samitova E.R. 8 , Skobeev D.A.2 , Starevskaya S.V.9 , Talalaev A.G.2 , Topilin O.G. 2 , Frolov P.A. 1
Номер выпуска
  • 1 Peoples’ Friendship, University of Russia, Moscow, Russian Federation
  • 2 Morozov Children’s City Clinical Hospital, Moscow, Russian Federation
  • 3 Children’s Infectious Clinical Hospital № 6, Moscow, Russian Federation
  • 4 Central City Hospital, Yaroslavl, Russian Federation
  • 5 Moscow State University of Medicine and Dentistry named after A.I. Evdokimov, Moscow, Russian Federation
  • 6 National Medical Research Center of Children’s Health, Moscow, Russian Federation
  • 7 I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation
  • 8 Z.A. Bashlyaeva Children City Clinical Hospital, Moscow, Russian Federation
  • 9 St. Petersburg Research Institute of Phthisiopulmonology, St. Petersburg, Russian Federation
Ключевые слова
Biopsy; COVID-19; Diagnosis; Interstitial lung disease; Neuroendocrine hyperplasia of infancy
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