Magnesium deficiency questionnaire: A new non-invasive magnesium deficiency screening tool developed using real-world data from four observational studies

Due to the high estimated prevalence of magnesium deficiency, there is a need for a rapid, non-invasive assessment tool that could be used by patients and clinicians to confirm suspected hypomagnesemia and substantiate laboratory testing. This study analyzed data from four large observational studies of hypomagnesemia in pregnant women and women with hormone-related conditions across Russia. Hypomagnesemia was assessed using a 62-item magnesium deficiency questionnaire (MDQ-62) and a serum test. The diagnostic utility (sensitivity/specificity) of MDQ-62 was analyzed using area under the receiver operating characteristic curve (AUROC). A logistic regression model was applied to develop a shorter, optimized version of MDQ-62. A total of 765 pregnant women and 8836 women with hormone-related conditions were included in the analysis. The diagnostic performance of MDQ-62 was “fair” (AUROC = 0.7−0.8) for women with hormone-related conditions and “poor” for pregnant women (AUROC = 0.6−0.7). The optimized MDQ-23 (23 questions) and MDQ-10 (10 questions) had similar AUROC values; for all versions of the questionnaire, there was a significant negative correlation between score and changes in total serum magnesium levels (p <0.0001 for all comparisons; correlation coefficients ranged from −0.1667 to −0.2716). This analysis confirmed the value of MDQ in identifying women at risk of hypomagnesemia. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.

Авторы
Orlova S. 1 , Dikke G.2 , Pickering G.3 , Konchits S.4 , Starostin K.4 , Bevz A.4
Журнал
Издательство
NLM (Medline)
Номер выпуска
7
Язык
Английский
Страницы
1-12
Статус
Опубликовано
Номер
2062
Том
12
Год
2020
Организации
  • 1 Department of Dietetics and Clinical Nutritiology of Continuing Medical Education, Medical Institute, RUDN University, Moscow, 119571, Russian Federation
  • 2 Department of Obstetrics and Gynecology with a Course of Reproductive Medicine, The Academy of Medical Education F.I. Inozemtsev, Saint-Petersburg, 190013, Russian Federation
  • 3 Department of Clinical Pharmacology, University Hospital and Inserm 1107 Fundamental and Clinical Pharmacology of Pain, Medical Faculty, Clermont-Ferrand, F-63000, France
  • 4 Medical Affairs, Sanofi, Moscow, 125009, Russian Federation
Ключевые слова
Hormone-related conditions; Hypomagnesemia; Magnesium deficiency questionnaire; Pregnancy
Дата создания
02.11.2020
Дата изменения
02.11.2020
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/64603/
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