Glutathione Synthesis in Cancer Cells

Abstract: Tripeptide GSH is associated not only with the control and maintenance of redox cell homeostasis, but also with the processes of detoxification, proliferation, cell differentiation, and regulation of cell death. Disruptions in GSH synthesis and changes in the GSH/GSSG ratio are common for many pathological conditions, including malignant neoplasms. Numerous data indicate the importance of GSH and the GSH/GSSG ratio in the regulation of tumor cell viability, in the initiation of tumor development, progression, and drug resistance. However, control of the mechanism of GSH synthesis in malignant tumors remains poorly understood. This review discusses the features of GSH synthesis and its regulation in tumor cells. The role of GSH in the mechanisms of apoptosis, necroptosis, ferroptosis, and autophagy is considered. © 2020, Pleiades Publishing, Ltd.

Авторы
Редакторы
-
Журнал
Издательство
-
Номер выпуска
8
Язык
Английский
Страницы
895-907
Статус
Опубликовано
Подразделение
-
Номер
-
Том
85
Год
2020
Организации
  • 1 Peoples’ Friendship University of Russia (RUDN University), Moscow, 117198, Russian Federation
Ключевые слова
apoptosis; autophagy; de novo GSH synthesis; ferroptosis; microRNA; necroptosis
Дата создания
02.11.2020
Дата изменения
02.11.2020
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/64485/