The impact of trauma of the mucous membrane of the nasal septum in rats on behavioral responses and changes in the balance of the autonomic nervous system (pilot study)

The nasal cavity surgery are usually traumatic surgery. Septoplasty leads to reactive inflammation, edema and hypoxemia. In the present study, we study the response of the autonomic nervous system (ANS), its role in changing behavioral reactions, as well as possible mechanisms of impairment of cognitive and adaptive reactions in rats after trauma to the nasal septum mucosa. The nasal septum mucosa was scarified in 10 adult mongrel male rats. The day before surgery and 2 days after surgery animals were tested in the square-shaped "open field" (OF) and electrocardiogram (ECG) in 1 hour before OF. ANS condition was analyzed by the high-frequency component of the heart rate (HF) and the low-frequency component of the heart rate (LF). The correlation of HF & LF with rat behavior in the open field before and after surgery was performed. Simulation of septoplasty in rats provokes a powerful stress response in the form of a sharp imbalance of ANS towards its PNS on the 2 postoperative day. Changes in behavioral and research reactions of rats in OF are manifested in a decrease in research activity, a display of uneasiness, depression-like state, as well as anxiety. © 2020 IOP Publishing Ltd. All rights reserved.

Сборник материалов конференции
Издательство
Institute of Physics Publishing
Номер выпуска
1
Язык
Английский
Статус
Опубликовано
Номер
012054
Том
1611
Год
2020
Организации
  • 1 Department of Physiology, Rudn University, Miklukho-Maklaya str.6, Moscow, 117198, Russian Federation
Ключевые слова
Electrocardiography; Heart; Rats; Surgery; Adaptive reaction; Autonomic nervous system; Behavioral response; High frequency components; Low-frequency components; Possible mechanisms; Post-operative days; Research activities; Behavioral research
Дата создания
02.11.2020
Дата изменения
02.11.2020
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/64470/