Hair trace element concentrations in autism spectrum disorder (ASD) and attention deficit/hyperactivity disorder (ADHD)

Background: The existing data demonstrate that alteration of trace element and mineral status in children with neurodevelopmental disorders including ASD and ADHD. However, comparative analysis of the specific patterns of trace element and mineral metabolism in children with ASD and ADHD was not performed. Therefore, the primary objective of the present study was to assess hair trace element and mineral levels in boys with ADHD, ASD, as well as ADHD with ASD. Methods: Boys with ADHD (n = 52), ASD (n = 53), both ADHD and ASD (n = 52), as well as neurotypical controls (n = 52) were examined. Hair analysis was performed using inductively-coupled plasma mass-spectrometry. Results: The obtained data demonstrate that hair Co, Mg, Mn, and V levels were significantly reduced in children with ADHD and ASD, and especially in boys with ADHD + ASD. Hair Zn was found to be reduced by 20% (p = 0.009) only in children with ADHD + ASD as compared to healthy controls. Factor analysis demonstrated that ASD was associated with significant alteration of hair Co, Fe, Mg, Mn, and V levels, whereas impaired hair Mg, Mn, and Zn content was also significantly associated with ADHD. In regression models hair Zn and Mg were negatively associated with severity of neurodevelopmental disorders. The revealed similarity of trace element and mineral disturbances in ASD and ADHD may be indicative of certain similar pathogenetic features. Conclusion: The obtained data support the hypothesis that trace elements and minerals, namely Mg, Mn, and Zn, may play a significant role in development of both ADHD and ASD. Improvement of Mg, Mn, and Zn status in children with ASD and ADHD may be considered as a nutritional strategy for improvement of neurodevelopmental disturbances, although clinical trials and experimental studies are highly required to support this hypothesis. © 2020 Elsevier GmbH

Skalny A.V. 1, 2, 3 , Mazaletskaya A.L.1 , Ajsuvakova O.P. 1, 2, 3 , Bjørklund G.4 , Skalnaya M.G. 2, 3 , Notova S.V.2, 5 , Chernova L.N. 3 , Skalny A.A. 1, 3 , Burtseva T.I.2, 6 , Tinkov A.A. 1, 2, 3
Elsevier GmbH
  • 1 Yaroslavl State University, Sovetskaya St., 14, Yaroslavl, 150003, Russian Federation
  • 2 IM Sechenov First Moscow State Medical University, Bolshaya Pirogovskaya St., 9, Moscow, 119146, Russian Federation
  • 3 RUDN University, Miklukho-Maklaya St., 6, Moscow, 117198, Russian Federation
  • 4 Council for Nutritional and Environmental Medicine, Mo i Rana, 8602, Norway
  • 5 Federal Research Centre of Biological Systems and Agro-technologies of the Russian Academy of Sciences, 9 Yanvarya St., 29, Orenburg, 460000, Russian Federation
  • 6 Orenburg State University, Pobedy Ave., 46, Orenburg, 460000, Russian Federation
Ключевые слова
Comorbidity; Magnesium; Manganese; Neurodevelopmental disorders; Zinc
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