Dietary ginger administration attenuates oxidative stress and immunosuppression caused by oxytetracycline in rainbow trout (Oncorhynchus mykiss)

In the present study, potential ameliorative effects of dietary ginger (GN) were investigated on antioxidant and immune responses of rainbow trout (Oncorhynchus mykiss) during oxytetracycline (OX) administration. As a 2 × 3 factorial design, the fish were orally treated with OX (a daily dose of 100 mg/kg) and GN (either 10 or 20 g/kg diet) for 10 days. Then, blood samples were taken from each treatment to monitor plasma lysozyme, complement (ACH50), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione-S-transferase (GST) activities, and reduced glutathione (GSH), malondialdehyde (MDA), total immunoglobulin (Ig) and globulin levels. OX treatment significantly decreased SOD (30%), GPx, (10%) and lysozyme (23%) activities, and GSH (19%) levels; however, it increased GST (16%) activity and MDA (28%) levels. Ten grams GN per kg levels significantly decreased SOD (35%), CAT (13%), GST (20%) and MDA (30%), but increased GSH (30%), lysozyme (48%) and globulin (16%). Twenty grams GN per kg diet significantly decreased SOD (26%) and MDA (17%), but increased lysozyme (31%) levels. Interaction effects of dietary GN and OX were observed on plasma MDA and GPx levels, as 10 g GN per kg diet prevented the OTC-induced changes in these parameters. Moreover, 20 g GN per kg diet prevented the OX-induced change in GPx activity and mitigated the MDA elevation by 20%. It is concluded that GN administration at 10 g/kg diet is beneficial in mitigating oxidative stress and immunosuppression of rainbow trout during OX administration. © 2020 John Wiley & Sons Ltd

Авторы
Zargar A.1, 2 , Taheri Mirghaed A. , Mirzargar S.S.1 , Ghelichpour M.1, 2 , Yousefi M. 3 , Hoseini S.M.2, 4
Редакторы
-
Журнал
Издательство
Blackwell Publishing Ltd
Номер выпуска
10
Язык
Английский
Страницы
4215-4224
Статус
Опубликовано
Подразделение
-
Номер
-
Том
51
Год
2020
Организации
  • 1 Department of Aquatic Animal Health, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
  • 2 Center for International Scientific Collaboration (CISC), Ministry of Science Research and Technology, Tehran, Iran
  • 3 Department of Veterinary Medicine, Peoples’ Friendship University of Russia (RUDN University), Moscow, Russian Federation
  • 4 Inland Waters Aquatics Resources Research Center, Iranian Fisheries Sciences Research Institute, Agricultural Research, Education and Extension Organization, Gorgan, Iran
Ключевые слова
antibiotic; antioxidant; health; herbal treatment; immune
Дата создания
02.11.2020
Дата изменения
02.11.2020
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/64364/