Trace element levels are associated with neuroinflammatory markers in children with autistic spectrum disorder

The objective of the present study was to estimate the association between brain inflammatory markers and serum trace element levels as assessed by inductively coupled plasma mass spectrometry at NexION 300D. Leukocyte elastase (LE), α1-proteinase inhibitor (α1-PI) activity, anti-nerve growth factor-antibodies (anti-NGF-Ab), and anti-myelin basic protein-antibodies (anti-MBP-Ab) levels were assessed as inflammatory markers. The obtained data demonstrate that the increase in LE and α1-PI activity is associated with higher serum Cr and Cu levels, respectively. The increase in Anti-NGF-Ab levels was associated with a nearly significant 16% increase in serum Mn levels. Autistic children with high MBP-Ab levels were characterized by 28% higher serum Mn and lower Mg concentration. The results of correlation analysis were generally in agreement with the outcome of group comparisons. Regression analysis demonstrated that serum Mg was significantly negatively associated with LE activity, whereas both serum Fe and V concentrations were characterized by a positive influence on the parameter. In turn, serum Cu was a significant predictor of α1-PI, as well as Cr levels. At the same time, the serum concentrations of Cd and Fe were found to be inversely associated with α1-PI levels. Serum Cd and Mn levels were significant positive predictors of anti-MBP-Ab levels, whereas Mg levels had a negative impact on anti-MBP-Ab values. Generally, the obtained data demonstrate the interrelationship between trace element homeostasis and neuroinflammation in autism. Hypothetically, modulation of trace element status may be used for reduction of neuroinflammatory response, although further studies are required to reveal the underlying mechanisms of the observed associations. © 2018 Elsevier GmbH

Skalny A.V. 1, 2, 3 , Simashkova N.V.4 , Skalnaya A.A.5 , Klyushnik T.P.4 , Zhegalova I.V. 1, 6 , Grabeklis A.R. 1, 2 , Skalnaya M.G. 1 , Tinkov A.A. 1, 2
Elsevier GmbH
  • 1 Yaroslavl State University, Sovetskaya St., 14, Yaroslavl, 150000, Russian Federation
  • 2 Peoples’ Friendship University of Russia (RUDN University), Miklukho-Maklaya St., 6, Moscow, 105064, Russian Federation
  • 3 Orenburg State University, Pobedy Ave., 13, Orenburg, 460352, Russian Federation
  • 4 Scientific Center for Mental Health, Russian Academy of Medical Sciences, Moscow, Russian Federation
  • 5 Lomonosov Moscow State University, Leninskie Gory, 1, Moscow, 119991, Russian Federation
  • 6 I.M. Sechenov First Moscow State Medical University, Malaya Trubetskaya St., 8, Moscow, 119992, Russian Federation
Ключевые слова
Autism spectrum disorders; Cadmium; Magnesium; Manganese; Neuroinflammation
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