The article attempts to give scientific justification to rational construction of the National strategy of overcoming turbulence in the innovative development of Russian industrial enterprises that is expected to help identify new competitive advantages and improve those connected with the growth of scientific and technological potential, of both the state and business. It is argued that in the current socio-economic conditions, the most promising direction is the development of cutting-edge technologies. The role of knowledge, innovation market, and other points of high-tech growth are determined. The necessity of the development of innovative territorial clusters based on the interaction between representatives of science, business and the government is substantiated. The choice of priority directions of innovation development is made keeping in mind international institutional, scientific, technical and technological forecasts and trends and is aimed at successful identification of the determinants of high-tech growth and formation of competitive advantages of the Russian economy that will allow to overcome the turbulence in the innovative development of the Russian economy. © Serials Publications Pvt. Ltd.