Use of low-frequency ultrasound in the combination treatment of the hypoplastic type of chronic endometritis

Objective. To evaluate the efficiency of treatment in patients with the hypoplastic type of chronic endometritis (CE) by uterine cavity irrigation with cavitation drug solutions exposed to low-frequency ultrasound (LFUS). Subjects and methods. 128 women diagnosed with the hypoplastic type of CE were examined. hypoplastic option. 64 patients of a study group (Group 1) received drug therapy and irrigation with a 0.05% cavitation chlorhexidine solution exposed to LFUS and with an immunomodulator solution (a total of 3 cycles). 64 patients of a comparison group (Group 2) had drug therapy only. The results were assessed by the time course of changes in the size of M-echo, endometrial histological examination before and after treatment, the occurrence of pregnancy and its outcomes. Results. The pretreatment endometrial thickness (M-echo data) was 5.8 ± 0.8 mm in Group 1 and 5.8 ± 0.5 mm in Group 2 (p = 0.899), the posttreatment one was 8.6 ± 0.3 and 6.4 ± 0.9 mm, respectively (p = 0.000). In the patients of the study group, the histological pattern in the endometrial biopsy specimens was observed to normalize in 11 (17.2 ± 0.05) and 64 (100%) patients after cycle treatments 2 and 3, respectively. In the comparison group, the endometrium after 4 and 6 months of treatment corresponded to the phase of the cycle in 2 (3.1% ± 0.02) and 18 (28.1% ± 0.06) women, respectively. In the first year after the end of therapy, pregnancy occurred substantially more commonly in Group 1 than in the comparison group (45.3 versus 28.15%). Pregnancy ended in childbirth in 89.7% of the patients in Group 1 and in 44.4% in Group 2; in these groups, there were miscarriages in 10.3 and 55.6%, respectively. Conclusion. Thus, LFUS used in patients with the hypoplastic type of CE promotes the adequate growth of the endometrium and the creation of favorable conditions for ovum implantation. © Bionika Media Ltd.