A Metal-Free Oxidative Dehydrogenative Diels–Alder Reaction for Selective Functionalization of Alkylbenzenes

Functionalization of C(sp3)−H bonds under metal-free reaction conditions is a great challenge due to poor bond reactivity. A novel metal-free oxidative dehydrogenative Diels–Alder reaction of alkylbenzene derivatives with alkenes through C(sp3)−H bond functionalization is described. The developed oxidative method provides a straightforward approach to biologically relevant 1,4-phenanthraquinone and isoindole derivatives from readily available starting materials. Furthermore, the synthesis of nitrostyrenes from enylbenzene derivatives by selective C(sp3)−H bond functionalization has been demonstrated. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

Авторы
Manna S.1, 2 , Antonchick A.P. 1, 2, 3
Редакторы
-
Издательство
Wiley-VCH Verlag
Номер выпуска
32
Язык
Английский
Страницы
7825-7829
Статус
Опубликовано
Подразделение
-
Номер
-
Том
23
Год
2017
Организации
  • 1 Abteilung Chemische Biologie, Max-Planck-Institut für Molekulare Physiologie, Otto-Hahn-Strasse 11, Dortmund, 44227, Germany
  • 2 Fakultät Chemie und Chemische Biologie, Technische Universität Dortmund, Otto-Hahn-Strasse 4a, Dortmund, 44227, Germany
  • 3 Faculty of Science, Peoples' Friendship University of Russia, 6 Miklukho-Maklaya Street, Moscow, 117198, Russian Federation
Ключевые слова
cycloaddition; C−H activation; dehydrogenative coupling; metal-free synthesis; oxidative coupling
Дата создания
19.10.2018
Дата изменения
19.10.2018
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/6162/