Association of Interleukin-31 gene polymorphisms with risk of cryptorchidism in a Chinese population

This study aims to investigate the possible association between Interleukin-31 (IL-31) gene polymorphisms and cryptorchidism risk.Two single nucleotide polymorphisms of IL-31, rs7977932 (C/G) and rs4758680 (C/A), were selected to be investigated in this study. Polymerase chain reaction-restriction fragment length polymorphism methods were used to discriminate the selected single nucleotide polymorphisms of IL-31 gene. A hospital-based case-control study of 112 cryptorchidism patients and 425 healthy controls was conducted.The frequencies of the C allele of rs4758680 in the patients with cryptorchidism were significantly higher compared with those in controls (89% vs 83%, P = .02, OR = 0.58, 95% CI = 0. 37-0.92). Compared with CC genotype in dominant model, notable decreased frequencies of A carriers (CA/AA genotypes) were observed in cryptorchidism patients (P = . 03, OR = 0.58, 95% CI = 0.35-0.96).Results demonstrated that IL-31 gene polymorphisms were associated with the genetic susceptibility to cryptorchidism in a Chinese population. Compared with CC genotype, the A carriers (CA/AA genotypes) of rs4758680 were protect factors in cryptorchidism susceptibility.

Авторы
Zou B. 1, 2 , Huang J. 1, 2 , Tan C. 1, 2 , Wang H. 1, 2 , Fu J. 1, 2 , Li X. 1, 2 , Wang X. 1, 2 , Cui S. 1, 2 , Tang T. 1, 2 , Yu Z.3
Журнал
Издательство
Lippincott Williams & Wilkins
Номер выпуска
22
Язык
Английский
Страницы
e15861
Статус
Опубликовано
Том
98
Год
2019
Организации
  • 1 Department of Urology
  • 2 Urogenital Diseases Lab|Affiliated Hospital of North Sichuan Medical College
  • 3 Department of Urology|Chongqing Three Gorges Central Hospital
Дата создания
20.02.2020
Дата изменения
20.02.2020
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/60355/