Sustainable, Oxidative, and Metal-Free Annulation

Annulation has received steadily growing interest in the interplay with the increasing emphasis towards selective C−H bond functionalization reactions. Metal-free oxidative annulation through functionalization of inert and abundant C−H bonds offers great improvements in terms of atom- and step-economics as well as reduced waste production under mild reaction conditions. Annulation is considered to be a highly efficient strategy for the construction of cyclic molecules because at least two new bonds are formed within a single reaction step. The combination of annulation and direct C−H bond functionalization allows the efficient and straightforward synthesis of carbo- and heterocyclic molecules using simple and non-prefunctionalized precursors. This Concept highlights novel strategies and recent breakthroughs for metal-free annulation through C−H bond functionalization giving access to a variety of important structural motifs. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

Авторы
Bering L.1, 2 , Manna S.1, 2 , Antonchick A.P. 1, 2, 3
Редакторы
-
Издательство
Wiley-VCH Verlag
Номер выпуска
46
Язык
Английский
Страницы
10936-10946
Статус
Опубликовано
Подразделение
-
Номер
-
Том
23
Год
2017
Организации
  • 1 Abteilung für Chemische Biologie, Max-Planck-Institut für Molekulare Physiologie, Otto-Hahn-Straße 11, Dortmund, 44227, Germany
  • 2 Fakultät Chemie und Chemische Biologie, Technische Universität Dortmund, Otto-Hahn-Straße 4a, Dortmund, 44221, Germany
  • 3 Faculty of Science, Peoples' Friendship University of Russia, 6 Miklukho-Maklaya Street, Moscow, 117198, Russian Federation
Ключевые слова
annulation; C−H bond functionalization; green chemistry; metal-free; sustainable methods
Дата создания
19.10.2018
Дата изменения
19.10.2018
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/6029/