Effect of acute hypoxia on resistance to hypoxia in rats

The resistance of rats to hypoxia was measured by survival time after exposure to high-altitude (11.5 km) hypoxia. The first exposure to acute hypoxia caused phasic changes in the survival time: short-term in high-resistant rats (about 24 h) and long-term in moderate- and low-resistant rats (38-39 days) starting from l h and 6-7 days after the first exposure, respectively. Adaptive reactions were more pronounced in low- and moderate-resistant rats, while disadaptation was typical of high-resistant animals. In all rats, the adaptive effect dominated until days 22-23. Throughout the testing, the initial type of resistance was retained in 79% of high-resistant rats, in 41% of low-resistant and in 33% of moderate-resistant rats, i. e., the initially homogenous groups formed after the first exposure in accordance with the type of resistance became mixed, which reduced the intergroup differences. ©1999 Kluwer Academic/Plenum Publishers.

Авторы
Agadzhanyan N.A. 1 , Khachatur'yan M.L.2 , Panchenko L.A.3
Редакторы
-
Издательство
New York Consultants BureauSpringer / Автономная некоммерческая организация Издательство Российской академии медицинских наук
Номер выпуска
6
Язык
Английский
Страницы
567-570
Статус
Опубликовано
Подразделение
-
Номер
-
Том
127
Год
1999
Организации
  • 1 Department of Normal Physiology, Russian University of People Friendship, Russian Federation
  • 2 Department of Experimental and Laboratory Models, Russian State Medical University, Russian Federation
  • 3 Departments of Vertebrate Zoology and General Ecology, Biological Faculty, M.V. Lomonosov Moscow State University, Russian Federation
Ключевые слова
Acute hypoxia; Resistance
Дата создания
19.10.2018
Дата изменения
19.10.2018
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/599/