One of the most pressing problems in dentistry today is the problem of intolerance to plastics (acrylates). The number of patients who use acrylic plastic dentures is constantly growing, which is due to the increase in the average life expectancy of people and the widespread pathology of hard dental tissues, as well as periodontal disease, which is the main cause of tooth loss. Along with the increase in the number of people who use dentures, the number of patients who can not use them for various reasons is growing. Violation of the ratio of anaerobic and aerobic microorganisms, changes in the level of total microbial contamination, the quantitative content of certain types of bacteria and the frequency of their detection-microecological disorders of the oral mucosa (COP), which are detected in patients. 111 patients were examined. The first group - 37 people with hyperthyroidism, the second group-50 patients with hyperthyroidism on the background of complex orthopedic and medical treatment. The control groups 1 and 2 included 15 and 19 patients. Intolerance syndrome develops after the installation of removable plate processes from acrylic plastics, this occurs together with the inflammatory process in periodontal tissues, the level of the total microbial number increases, dysbiotic processes are expressed, the ratio of Airbus/anaerobes changes towards the prevalence of anaerobes.