A Search for Similar Patterns in Hair Trace Element and Mineral Content in Children with Down’s Syndrome, Obesity, and Growth Delay

The objective of the present study was to perform comparative analysis of hair trace element and mineral levels in children with Down’s syndrome, growth delay, and obesity in order to reveal common and specific patterns. Hair Zn (14, 7, and 15%), Ca (38%, 24%, and 47%), and Mg (33%, 31%, and 49%) levels in children with Down’s syndrome, obesity, and growth delay were lower than the respective control values. At the same time, patients with Down’s syndrome and growth delay were characterized by 27% and 21%, as well as 24% and 20% lower hair Co as well as Cu content than healthy examinees. Certain alterations were found to be disease-specific. Particularly, in Down’s syndrome children, hair Cr, Fe, and V levels were significantly lower, whereas hair P content exceeded the control values. Obese children were characterized by significantly increased hair Cr content. At the same time, hair Mn and Si levels in children with growth delay were lower as compared with the controls. In regression models, all three studied diseases were considered as negative predictors of hair Cu content. Down’s syndrome and growth delay, but not obesity, were inversely associated with hair Co content. Both Down’s syndrome and obesity were inversely associated with hair Zn content. Based on the revealed similarities in altered hair element, content it is proposed that deficiency of essential elements may predispose Down’s syndrome patients to certain syndrome comorbidities including growth delay and obesity, although further detailed studies are required. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.

Grabeklis A.R. 1, 2 , Skalny A.V. 1, 2, 3 , Ajsuvakova O.P. 1, 2, 3 , Skalnaya A.A. 4 , Mazaletskaya A.L.1 , Klochkova S.V. 3 , Chang S.J.S.5, 6 , Nikitjuk D.B.3, 7 , Skalnaya M.G. 1, 2, 3 , Tinkov A.A. 1, 2, 3
Humana Press Inc.
  • 1 Yaroslavl State University, Yaroslavl, 150003, Russian Federation
  • 2 Peoples’ Friendship University of Russia (RUDN University), Moscow, Russian Federation
  • 3 IM Sechenov First Moscow State Medical University (Sechenov University), Moscow, 119146, Russian Federation
  • 4 Research Center of Neurology, Moscow, 105064, Russian Federation
  • 5 College of Nutrition, Taipei Medical University, Taipei, 11031, Taiwan
  • 6 Nutrition Research Center, Taipei Medical University Hospital, Taipei, 11031, Taiwan
  • 7 The Federal Research Centre of Nutrition, Biotechnology and Food Safety, Moscow, Russian Federation
Ключевые слова
Cobalt; Comorbidity; Copper; Trisomy 21; Zinc
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