Materials on the study of progestogenic, gonadotropic, selenium-containing and immunocorrective agents' effectiveness for the prevention of fetal development disorders in cows are present in the article. The aim of the research: is to study of pharmacological agents effectiveness for the prevention of early embryogenesis disorders in cows. Materials and methods: The studies were carried out on black-and-white cows with an average annual milk production of 5.5-7.5 thousand kg with tie-up and yard housing at various times after calving. Efficacy evaluation of methods for preventing intrauterine growth retardation and mortality of embryos and fetuses was carried out at 30-32 and 60-65 days after insemination by ultrasound. Diagnosis of intrauterine growth retardation syndrome of the embryo and fetus in cows was carried out retrospectively. The results of the study: The prophylactic efficacy of progestagam was 60.0%, follymag combined with selemag - 61.5%, and bovine recombinant interferon-tau - 66.7%. Pregnancy after the application of these preparations proceeds against the background of increased content of progesterone (higher by 16.4-52.2%), which favorably affects the development of the embryo and fetus, the length of which in the first two months of gestation is 35.8-56.9% more than intact animals. Conclusion: The most effective ways of preventing early embryogenesis disorders (fetal death, embryo and fetal growth retardation syndrome) are the use of progestogenic and gonadotropic drugs, as well as interferon-series drugs - interferon-tau. © 2019 Popova et al.