EVALUATION OF DYNAMIC TELOMERE LENGTH SHORTENING OF LYMPHOCYTES IN IMMUNOCOMPROMISED CHILDREN WITH CHRONIC DISEASES OF THE RESPIRATORY

Nowadays it is common to observe the growth of viral-viral and viral-bacterial co-infections in children of different ages, due to dysfunction of lymphocytes (DL), which can be connected with the process of the accelerated shortening of the end structures of chromosomal telomeres, telomere length changes are described in lymphocytes of children with chronic mono-infections. The conducted study has shown the shortening of telomere lymphocytes in children with CDRT seropositive for mixed-herpes viral infections (herpes simplex virus, virus, Epstein-Barr virus and cytomegalovirus in various combinations) and for bacterial co-infections - Chlamydia trachomatis and (or) Mycoplasma pneumoniae. The use of regression analysis and attribute analysis (in percent) made possible to neutralize age-groups differences of seropositive and seronegative children. Thus showed that children, who suffer from chronic diseases of the respiratory tract associated with mixed-herpes viral and bacterial co-infections, have more pronounced telomere shortening of lymphocytes than seronegative children of the same age.

Авторы
Khalturina E.1 , Nesterova I.1
Журнал
Издательство
Ассоциация деловой прессы Грузии
Номер выпуска
266
Язык
Русский
Страницы
99-103
Статус
Опубликовано
Год
2017
Организации
  • 1 1I.M. Sechenov First Moscow State Medical University, Moscow
  • 2 2Russian University of peoples friendship, Moscow, Russia
Ключевые слова
blood; child; chlamydiasis; chronic disease; herpes virus infection; human; immunocompromised patient; immunology; lymphocyte; mixed infection; mycoplasmosis; preschool child; respiratory tract infection; telomere shortening; ultrastructure; Child; Child, Preschool; Chlamydia Infections; Chronic Disease; Coinfection; Herpesviridae Infections; Humans; Immunocompromised Host; Lymphocytes; Mycoplasma Infections; Respiratory Tract Infections; Telomere Shortening
Дата создания
19.10.2018
Дата изменения
19.10.2018
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/5520/