Gut microbiota and vascular biomarkers in patients without clinical cardiovascular diseases

The aim of this research was to study the association between the gut microbiota composition and arterial wall properties. The study included 92 participants, men and women aged 25–76 years old without clinical manifestation of chronic diseases but with the possible presence of cardiovascular risk factors. Carbohydrate metabolism examination, duplex scanning of the carotid arteries with the measurement of the intima-media thickness (IMT), the carotid-femoral pulse wave velocity (PWV) measurement, and 16S rRNA (V3[sbnd]V4 regions) sequencing of the gut microbiota were performed in all participants. Higher Serratia abundance was associated with the increased IMT and CRP levels. Blautia representation was associated with IMT. Higher Bacteroides representation was associated with higher pulse wave velocity in non-diabetic subjects. Although this study had some limitations, we have demonstrated that the composition of the gut microbiota was associated both with atherosclerotic and arterial stiffness markers. © 2017 Association for Research into Arterial Structure and Physiology

Авторы
Kashtanova D.1, 3 , Tkacheva O.3 , Popenko A.2 , Egshatyan L.4 , Tyakht A.2 , Alexeev D.6 , Kotovskaya Y. 3, 5 , Plokhova E.3 , Boytsov S.1
Журнал
Издательство
Elsevier Ltd
Номер выпуска
Issue C
Язык
Английский
Страницы
41-48
Статус
Опубликовано
Том
18
Год
2017
Организации
  • 1 National Research Centre for Preventive Medicine, Moscow, Russian Federation
  • 2 Institute for Physical-Chemical Medicine, Moscow, Russian Federation
  • 3 Pirogov Russian National Research Medical University, Russian Clinical Research Center for Gerontology, Moscow, Russian Federation
  • 4 Federal State Budgetary Establishment Endocrinology Research Centre, Russian Federation
  • 5 Peoples’ Friendship University of Russia
  • 6 Complex Biological Systems Lab, Moscow Institute of Physics and Technology (State University), 9 Institutskiy per., Dolgoprudny, Moscow Region, 141700, Russian Federation
Ключевые слова
Arterial stiffness; Atherosclerosis; Gut microbiota; Low-grade inflammation
Дата создания
19.10.2018
Дата изменения
02.06.2020
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/5500/