Role of MicroRNAs in the Regulation of Redox-Dependent Processes

Cellular redox homeostasis involves a combination of redox processes and corresponding regulatory systems and represents an important factor ensuring cell viability. Redox-dependent regulation of cellular processes is a multi-level system including not only proteins and enzyme complexes, but also non-coding RNAs, among which an important role belongs to microRNAs. The review focuses on the involvement of miRNAs in the redox-dependent regulation of both ROS (reactive oxygen species)-generating enzymes and antioxidant enzymes with special emphasis on the effects of miRNAs on redox-dependent processes in tumor cells. The impact of ROS on the miRNA expression and the role of the ROS/miRNA feedback regulation in the cell redox state are discussed. © 2019, Pleiades Publishing, Ltd.

Редакторы
-
Журнал
Издательство
-
Номер выпуска
11
Язык
Английский
Страницы
1233-1246
Статус
Опубликовано
Подразделение
-
Номер
-
Том
84
Год
2019
Организации
  • 1 Peoples’ Friendship University of Russia (RUDN University), Moscow, 117198, Russian Federation
Ключевые слова
cellular redox homeostasis; microRNA; reactive oxygen species
Дата создания
24.12.2019
Дата изменения
24.12.2019
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/54918/