Chemical Modification of Plant Alkaloids. 7. T-Reaction of an Aloperine Derivative

N-(2-Carboxy-5-nitrophenyl)aloperine was prepared from aloperine and 2-fluoro-5-nitrobenzaldehyde and condensed with 1,3-dimethylbarbituric acid via a T-reaction with opening of the piperidine ring and formation of 1,3-dimethyl-5-{5-nitro-2-[3-(10-oxo-7-azatricyclo[7.3.1.02,7]trideca-11-en-12-yl)propylamino]} benzylhexahydro-2,4,6-pyrimidinetrione. The structure of the prepared compound was studied by an X-ray crystal structure analysis. © 2017, Springer Science+Business Media, LLC.

Авторы
Krasnov K.A.1 , Kartsev V.G. 2 , Dobrokhotova E.V. 3 , Kultyshkina E.K. 3 , Timofeeva T.V.4 , Khrustalev V.N. 3, 5
Номер выпуска
4
Язык
Английский
Страницы
703-707
Статус
Опубликовано
Том
53
Год
2017
Организации
  • 1 Institute of Toxicology, Federal Medical and Biological Agency, 1 Bekhtereva St, St. Petersburg, 192019, Russian Federation
  • 2 ZAO Interbioscreen, 8 Institutskii Prosp, Moscow Oblast, Chernogolovka 142432, Russian Federation
  • 3 People’s Friendship University of Russia, 6 Miklukho-Maklaya St, Moscow, 117198, Russian Federation
  • 4 Department of Chemistry & Biology, New Mexico Highlands University, Las Vegas, NM 87701, United States
  • 5 Nesmeyanov Institute of Elementorganic Compounds, Russian Academy of Sciences, 28 Vavilova St, Moscow, 119991, Russian Federation
Ключевые слова
1,3-dimethyl-5-{5-nitro-2-[3-(10-oxo-7-azatricyclo[7.3.1.02,7]trideca-11-en-12-yl)propylamino]}benzylhexahydro-2,4,6-pyrimidinetrione; 1,3-dimethylbarbituric acid; aloperine; hydride shift; N-(2-carboxy-5-nitrophenyl)aloperine; T-reaction; tert-amine effect
Дата создания
19.10.2018
Дата изменения
19.10.2018
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/5467/