Polymorphism of Angiotensinogen T174M Gene and Cardiovascular Diseases in the Moscow Population

The groups of patients with myocardial infarction (MI) and hypertrophy of the left ventricle (HLV) (n = 45 and n = 53, respectively) and a sample of healthy individuals from the Moscow population (n = 60) were examined for T174M polymorphism of ACT gene (replacement of methionine for threonine at position 174 of the correspondent amino acid sequence). In MI patients the content of 7T genotypes and 7 allele was significantly lower than in the control group (57.8% against 80% and 67.9 against 89.2%, respectively), whereas the proportion of M allele and TM hétérozygotes was increased (32.1 against 10.8% and 37.8 against 18.3%, respectively). In patients with HLV, the proportion of 7T genotype (64.2%) and T allele (77.4%) was also lower than in the control group, whereas the frequency of M allele was increased (22.6%). Our results suggest that the T174M polymorphism of ACT gene is associated with MI and HLV in the Moscow population.

Авторы
Chistyakov D.A. 1 , Turakulov R.I.2 , Moiseev V.S. 2 , Nosikov V.V.2
Редакторы
-
Журнал
Издательство
-
Номер выпуска
8
Язык
Английский
Страницы
1160-1164
Статус
Опубликовано
Подразделение
-
DOI
-
Номер
-
Том
35
Год
1999
Организации
  • 1 State Research Institute of Genetics, Selection of Industrial Microorganisms, Moscow 113545, Russian Federation
  • 2 Russian University of People Friendship, Moscow 117272, Russian Federation
Ключевые слова
angiotensinogen; adult; article; case control study; female; genetic polymorphism; genetic predisposition; genetics; genotype; heart infarction; heart left ventricle hypertrophy; human; male; middle aged; Russian Federation; Adult; Angiotensinogen; Case-Control Studies; Female; Genetic Predisposition to Disease; Genotype; Humans; Hypertrophy, Left Ventricular; Male; Middle Aged; Moscow; Myocardial Infarction; Polymorphism, Genetic
Дата создания
19.10.2018
Дата изменения
19.10.2018
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/522/