A novel synthetic approach to hydroimidazo[1,5-b]pyridazines by the recyclization of itaconimides and HPLC-HRMS monitoring of the reaction pathway

The novel cascade two-stage reaction between itaconimides and 1,2-diamino-4-phenylimidazole proceeds regio- and chemoselectively to form tetrahydroimidazo[1,5-b]pyridazines and includes nucleophilic C-addition by the activated C=C double bond and subsequent intramolecular recyclization of the intermediate with the amino group involved. © 2017 Vandyshev et al.; licensee Beilstein-Institut.

Авторы
Vandyshev D.Y.1 , Shikhaliev K.S.1 , Potapov A.Y.1 , Krysin M.Y.1 , Zubkov F.I. 2 , Sapronova L.V. 2
Издательство
Beilstein-Institut Zur Forderung der Chemischen Wissenschaften
Язык
Английский
Страницы
2561-2568
Статус
Опубликовано
Том
13
Год
2017
Организации
  • 1 Faculty of Chemistry, Voronezh State University, Universitetskaya sq., 1, Voronezh, 394018, Russian Federation
  • 2 Faculty of Physics and Mathematics and Natural Sciences, RUDN University, Miklukho-Maklaya St., 6, Moscow, 117198, Russian Federation
Ключевые слова
Cascade reaction; Diaminoimidazoles; HPLC-HRESIMS; Imidazo[1,5-b]pyridazines; Itaconimides
Дата создания
19.10.2018
Дата изменения
13.08.2021
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/5172/
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