Palivizumab: Four seasons in Russia

In 2010, the Russian Federation (RF) registered palivizumab - innovative drug, based on monoclonal antibodies for passive immunization of seasonal respiratory syncytial virus (RSV) infection in children of disease severe progress risk group, which include primarily premature infants, children with bronchopulmonary dysplasia and hemodynamically significant congenital heart disease. Currently, palivizumab is included in the list of recommended medicines and medical care standards of different countries, including Russia. In the review the results of Russian research on the progress of RSV infection, its epidemiology and immunization experience gained over the 2010-2014 period are summarized in relation to the foreign data. During the four epidemic seasons palivizumab immunization covered more than 3,200 children of severe RSV infection risk group with a progressive annual increase in the number of patients who received the drug. Geography of palivizumab immunization is also greatly expanded in our country during this time. If during the first two seasons measures of immunization were taken mainly in Moscow and St. Petersburg, at the present time, thirty one territorial entities of the Russian Federation have the experience in the drug application. Analysis of the results of RSV infection immunization (made in several regions) confirms the high clinical efficacy and palivizumab safety already demonstrated in international studies. In addition, the analysis presents the potential to improve the efficiency of the integrated RSV infection immunization programs, realizing in the establishment of high-risk child group register, adequate counseling for parents, as well as the development of the routing of patients and coordination of interaction between different health institutions during the immunization. © 2014, Izdatel'stvo Meditsina. All rights reserved.

Baranov A.A.1, 2 , Ivanov D.O.3, 4 , Alyamovskaya G.A.5 , Amirova V.R.6, 7 , Antonyuk I.V.8 , Asmolova G.A.5, 9 , Belyaeva I.A.1 , Bokeriya E.L.10 , Bryukhanova O.A.7 , Vinogradova I.V.11, 12 , Vlasova E.V.13 , Galustyan A.N.14 , Gafarova G.V.15 , Gorev V.V.16 , Davydova I.V.1, 2 , Degtyarev D.N.17 , Degtyareva E.A. 5, 18, 19 , Dolgikh V.V.20 , Donin I.M.21 , Zakharova N.I. 19, 22 , Zernova L.Yu.23 , Zimina E.P.1 , Zuev V.V.24 , Keshishyan E.S.5 , Kovalev I.A.5 , Koltunov I.E. 19, 21 , Korsunskii A.A.2, 25 , Krivoshchekov E.V.26 , Krsheminskaya I.V. 18, 19 , Kuznetsova S.N.27 , Lyubimenko V.A.28 , Namazova-Baranova L.S.1, 2, 5 , Nesterenko E.V.29 , Nikolaev S.V.29 , Ovsyannikov D.Yu. 18, 19, 21 , Pavlova T.I.30 , Potapova M.V.31 , Rychkova L.V.20 , Safarov A.A.32 , Safina A.I.33 , Skachkova M.A.34, 35 , Soldatova I.G.5, 9 , Turti T.V.1 , Filatova N.A.36 , Shakirova R.M.37 , Yanulevich O.S.26
Номер выпуска
  • 1 Scientific Centre of Children's Health, Moscow, Russian Federation
  • 2 Department of Pediatric Faculty, I.M. Sechenov First Moscow State Medical University, bld. 1, 2, Lomonosov Ave., Moscow, 119991, Russian Federation
  • 3 Federal State Institution, Federal Almazov Medical Research Centre, St. Petersburg, Russian Federation
  • 4 North-Western State Medical University n.a. I.I. Mechnikov, St. Petersburg, Russian Federation
  • 5 N.I. Pirogov Russian National Research Medical University, Moscow, Russian Federation
  • 6 Clinical Maternity Hospital No 4, Ufa, Bashkortostan, Russian Federation
  • 7 Bashkir State Medical University, Ufa, Russian Federation
  • 8 Tyumen State Medical Academy, Russian Federation
  • 9 N.F. Filatov Children's Municipal Clinical Hospital No 13, Moscow, Russian Federation
  • 10 L.A. Vorokhobov City Clinical Hospital No 67, Moscow, Russian Federation
  • 11 Presidential Perinatal Centre of the Ministry of Public Health and Social Development of Chuvashia, Cheboksary, Russian Federation
  • 12 I.N. Ul'yanov Chuvash State University, Cheboksary, Russian Federation
  • 13 Regional Children's Clinical Hospital No 1, Ekaterinburg, Russian Federation
  • 14 St. Petersburg State Pediatric University, Russian Federation
  • 15 Child Health Center No 8, Ufa, Bashkortostan, Russian Federation
  • 16 Regional Perinatal Centre, Tomsk, Russian Federation
  • 17 V.I. Kulakov Research Center for Obstetrics, Gynecology and Perinatology, Moscow, Russian Federation
  • 18 Clinical Hospital for the Infectious Diseases of Children No 6, Moscow, Russian Federation
  • 19 Peoples' Friendship University of Russia, Moscow, Russian Federation
  • 20 Research Center of Family Health Problems and Human Reproduction, Irkutsk, Russian Federation
  • 21 Morozov City Children's Clinical Hospital, Moscow, Russian Federation
  • 22 Mytishchi City Clinical Hospital, Moscow region, Russian Federation
  • 23 Izhevsk State Medical Academy, Russian Federation
  • 24 Children's Clinical Hospital No 13, Perm, Russian Federation
  • 25 G.N. Speranskii Children's Clinical Hospital No 9, Moscow, Russian Federation
  • 26 Research Institute for Cardiology, Tomsk, Russian Federation
  • 27 Ivano-Matreninskaya Children's Hospital, Irkutsk, Russian Federation
  • 28 Children's City Hospital No 1, St. Petersburg, Russian Federation
  • 29 City Clinical Perinatal Centre, Omsk, Russian Federation
  • 30 Irkutsk Regional Clinical Hospital, Russian Federation
  • 31 City Children's Hospital No 1, Kazan, Tatarstan, Russian Federation
  • 32 Regional Perinatal Center of the Kaliningrad Region, Kaliningrad, Russian Federation
  • 33 Kazan State Medical Academy, Tatarstan, Russian Federation
  • 34 Orenburg State Medical Academy, Russian Federation
  • 35 Municipal Children's Clinical Hospital, Orenburg, Russian Federation
  • 36 St. Nicholas the Wonderworker Children's City Hospital No 17, St. Petersburg, Russian Federation
  • 37 Ministry of Health of the Republic of Bashkortostan, Ufa, Russian Federation
Ключевые слова
Children; Palivizumab; Preventive measures / prophylaxis; Respiratory syncytial virus infection; The organization of medical care
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